• Date：May 9, 2025 from 15:10 to 16:40
• Place：Research Center for Nuclear Physics (RCNP) Lecture Room on 6th floor, Suita Campus

Presenter:
1) MIYAMOTO Sodai (Chemistry)
Title: Synthesis and Characterization of Strongly Luminescent Nitridotechnetium(V) and Rhenium(V) Complexes
Abstract: In this study, we synthesized and characterized new nitridotechnetium(V) and nitridorhenium(V) complexes. The structures of all the new complexes were determined by single-crystal X-ray analysis. The complexes exhibited strong photoluminescence in the visible region at room temperature. The new technetium complexes in this study were found to have the highest emission quantum yields and longest emission lifetimes reported to date.

2) Paddy Melsen(Chemistry)
Title: Identification of a Novel KDM4C Inhibitor through Click Chemistry-Based Library- and DNA-Encoded Library Construction and Screening
Abstract: KDM4C has been implicated in glioblastoma (Cell Death Dis., 2021, 12, 89) and various other cancers, making it an attractive target for therapeutic intervention. Although several KDM4C inhibitors have been reported, achieving isoform selectivity remains a major challenge due to the high homology within the catalytic JmjC domain (J. Enzyme Inhib. Med. Chem., 2018, 33, 777–793). Given that KDM4A inhibition is linked to severe adverse effects (Blood., 2019, 134, 1154–1158), the development of KDM4C-selective inhibitors is crucial. By leveraging two high-throughput screening platforms—CuAAC-triazole- and DNA-encoded libraries (DEL)—this project aims to discover potent inhibitors and use kinetic binding analyses to identify kinetically selective inhibitors of KDM4C.