Graduate School of Medicine faculty of Medicine
I am currently researching the effects of ultra-High Dose Rate (uHDR) irradiation on the invasive capabilities of cancer cells. uHDR irradiation is a modern irradiation method that delivers a very high dose rate (radiation dose per unit time) (100 Gy/s or more) over a short period, surpassing typical clinical practice. This irradiation method has been reported to be effective in reducing adverse events in normal tissues of the human body and locally controlling cancer.
While much research on uHDR irradiation has been conducted using X-rays, protons, and electron beams, my focus is on carbon ion beams (heavy particle beams). uHDR carbon ion irradiation is a revolutionary irradiation method that can be performed at only a few institutions in the world.
In our research group, carbon ion irradiation at a normal dose rate (NDR) has been found to inhibit cancer invasion and metastasis. However, the effects of uHDR carbon ion irradiation on cancer cell behavior are not yet well understood. Therefore, we are conducting a comparative study of cell invasion ability between NDR and uHDR carbon ion irradiation. Additionally, unlike most radiobiology studies that focus on “radiation-induced cell death”, this study examines the behavior of surviving cells post-irradiation