Terumi Yokoyama
Department of Chemistry, Graduate School of Science

I am conducting research on complexes of Th-227 and Zr-89 with the aim of developing cancer therapeutics. Th-227 is an α-emitting radionuclide with promising applications in alpha-particle radiotherapy, while Zr-89 is a positron-emitting radionuclide used as a tracer for PET (positron emission tomography). Combining these radionuclides enables theranostics that integrate therapy and diagnosis. For clinical application, it is essential to develop chelators that can stably bind these radionuclides. In this study, we focus on the stability of Th and Zr complexes and aim to design and develop ligands suitable for both elements by systematically investigating ligand characteristics.