• 日時：2025年5月9日（金）15:10～16:40
• 場所：核物理研究センター本館6階　講義室２

<発表者>

1）宮本　颯大（化学専攻） Title: Synthesis and Characterization of Strongly Luminescent Nitridotechnetium(V) and Rhenium(V) Complexes Abstract: In this study, we synthesized and characterized new nitridotechnetium(V) and nitridorhenium(V) complexes. The structures of all the new complexes were determined by single-crystal X-ray analysis. The complexes exhibited strong photoluminescence in the visible region at room temperature. The new technetium complexes in this study were found to have the highest emission quantum yields and longest emission lifetimes reported to date.

2）Paddy MELSEN （化学専攻） Title: Identification of a Novel KDM4C Inhibitor through Click Chemistry-Based Library- and DNA-Encoded Library Construction and Screening Abstract:KDM4C has been implicated in glioblastoma (Cell Death Dis., 2021, 12, 89) and various other cancers, making it an attractive target for therapeutic intervention. Although several KDM4C inhibitors have been reported, achieving isoform selectivity remains a major challenge due to the high homology within the catalytic JmjC domain (J. Enzyme Inhib. Med. Chem., 2018, 33, 777–793). Given that KDM4A inhibition is linked to severe adverse effects (Blood., 2019, 134, 1154–1158), the development of KDM4C-selective inhibitors is crucial. By leveraging two high-throughput screening platforms—CuAAC-triazole- and DNA-encoded libraries (DEL)—this project aims to discover potent inhibitors and use kinetic binding analyses to identify kinetically selective inhibitors of KDM4C.